CINEMATOGRAPH EYE IRRITATION

1 Subgroup 3 . Eye Irritation

Application of Alternative Methods in the Regulatory Assessment of Chemical Safety Related to Human Eye Irritation & Severe Eye Irritation

Nasal, eye, and skin irritation in dockyard painters.

OBJECTIVES To determine whether the risk of irritant symptoms in painters is related to their exposure to paint. METHODS The prevalences of skin, eye and nasal symptoms were compared in 260 United Kingdom and 109 Chinese dockyard painters, 539 British community controls, and 255 Chinese dockyard controls, relative to their exposure to paints. RESULTS Painters showed an excess of irritant sy...

Surfactant-induced TRPV1 activity--a novel mechanism for eye irritation?

The pain receptor transient receptor potential vanilloid type 1 (TRPV1) has been reported as one of the key components in the pain pathway. Activation of the receptor causes a Ca2+ influx with secondary effects leading to neurogenic inflammation. Here we report specific activation of TRPV1 by detergent-containing hygiene products measured as intracellular Ca2+ influxes in stably TRPV1-expressin...

Alternative methods for the replacement of eye irritation testing.

In the last decades significant regulatory attempts were made to replace, refine and reduce animal testing to assess the risk of consumer products for the human eye. As the original in vivo Draize eye test has been criticized for limited predictivity, costs and ethical issues, several animal-free test methods have been developed to categorize substances according to the global harmonized system...